Building a medical campus

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1910s, 1920s, 1940s, 1950s, 1960s, 1970s, anatomy, biochemistry, library, medicine, microbiology, obstetrics and gynaecology, pharmacology, pharmacy, physiology, preventive and social medicine, surgery

An aerial view showing the medical school and hospital buildings, c.1970. The low-rise 1950s building replaced by the Sayers building can be seen between the Wellcome and Ferguson buildings, with cars parked in front. At the hospital, the clinical services building, opened in 1968, can be seen, but construction is yet to begin on the ward block, which opened in 1980. Several of the buildings in the block east of the hospital are now part of the university: the original Queen Mary maternity hospital now houses the surveying school and marine science department; the 2nd Queen Mary hospital is Hayward College, and the old nurses’ homes are Cumberland College. Image courtesy of the Hocken Collections, University of Otago Medical School Alumnus Association records, MS-1537/806, S17-517b.

There’s a significant university anniversary this year: it’s a century since the medical school opened its first Great King Street building. Otago medical classes started out in the university’s original building in Princes Street, but soon moved to the purpose-built anatomy and chemistry block (now the geology building) on the new site near the Leith. Opened in 1878, the new premises incorporated a lecture room, dissection room, preparation room, morgue, laboratory, anatomy room and professor’s office for the medical school. The facilities weren’t large – they were designed to cater for classes of a dozen or so – and the building was extended in 1883 and again in 1905, to provide for the expanding school and its first physiology professor. As medical student numbers continued to expand, from 80 in 1905 to 155 in 1914, space became desperately short and the medical faculty won government approval for further extensions to the anatomy and physiology departments, plus a new building to house the pathology and bacteriology (microbiology) departments, along with other subjects being taught in far from ideal conditions in the crowded hospital.

The site of the new building – in Great King Street, opposite the hospital – was controversial. Some university council members wanted all new developments to be on the existing campus, but medical academics wanted to be closer to the hospital, and the chancellor, Andrew Cameron, was on their side. Sydney Champtaloup, professor of public health and bacteriology, revealed the thinking behind the move during the 1914 public appeal for funds for the new building. After completing their studies in anatomy and physiology, which would still be taught at the university, said Champtaloup, ‘students are intimately associated with the Hospital. At present students attend some classes at the University, and have then to proceed to the Hospital for others, and to return to the University later. This involves a great waste of time and energy. All lectures and practical classes for senior students should be held in a suitable building near the Hospital’. He also pointed out that the hospital and university both required bacteriology and pathology labs, and ‘a combination of these requirements in one building makes for efficiency and economy, but that building to meet Hospital requirements must be either in the Hospital grounds or in its close proximity’. Although he didn’t mention it, Champtaloup would have to waste considerable time and energy himself if the new building wasn’t close to the hospital, since he was in charge of its bacteriology services.

The bacteriology and pathology building, later known as the Scott building, which opened in 1917. Image courtesy of the Hocken Collections, University of Otago Medical School Alumnus Assocation records, MS-1537/636, S17-517a.

The public appeal raised the goodly sum of £8000 (over $1 million in 2017 values), which included £2000 from William Dawson (a brewer who made a fortune as one of the founders of Speight’s) and £1000 from members of the medical faculty. It was matched by the government, though the project ran considerably over budget thanks to ‘the presence of subterranean water, later found to characterise the whole area’, along with rising prices due to war conditions. The new building, designed by Mason and Wales and built by Fletcher Brothers, opened in 1917. Of brick with Oamaru stone facings, its neoclassical style seemed quite plain to contemporaries; the Evening Star noted some ‘pretty stained glass’ in the entrance hall was ‘one of the few ornamentations’. The building was large and well-lit, with a lecture theatre able to ‘seat 150 students and give everyone plenty of elbow room’ and other smaller lecture rooms; they incorporated facilities for the latest technology, the lantern slide. The pathology department was on the first floor and the bacteriology department on the second floor; there were also rooms dedicated to medical jurisprudence and materia medica (pharmacology), the library, specimen museum and an assortment of staff and student facilities. ‘The roof is used for store rooms, etc.’, reported the Star with some delicacy; that was where animals and food stores were housed.

The new building was just the beginning. Medical dean Lindo Ferguson had ambitious plans; he imagined the school expanding to take up the entire side of the Great King Street block facing the hospital, replacing its collection of old cottages and shops. Not everybody approved, and there was another battle over the new anatomy and physiology building. In 1919 university council members decided that further extensions to those departments should be on the main university campus, provoking a determined – and successful – campaign by the medical faculty, medical association and ODT to have them change their minds and instead construct a large new building adjoining the 1917 one. Physiology professor John Malcolm countered one of the main objections to the Great King Street site: ‘It had been said that the social life of the university was cut in two through the existing arrangements; and if that were so how about the scientific life of the university? Was it not cut in two as well? The most important was the human life’. After considerable delays in raising funds, in 1927 a splendid new building – ‘one of Dunedin’s most handsome’, declared the ODT – was opened. Designed by Edmund Anscombe in brick and stone facings to complement its neighbour, it provided accommodation for not just anatomy and physiology, but also the ‘sub-departments’ of histology, biochemistry and pharmacology. It had the ‘necessary classrooms, laboratories, and research rooms for a school averaging an annual class of 50 students’.

At the opening of the new block, Ferguson joked that ‘if a dean were content he was not fit to hold his position. No one knew the shortcomings of a school better than the dean, and if the dean thought that enough had been done he should be pole-axed’. He continued to dream of further expansion, and had already foiled suggestions the new dental school building should be immediately next to the medical school; instead its new 1926 building (now the Marples building) was constructed on the next block. Ferguson’s successors took up his scheme and in the midst of World War II work began on yet another large building. It had the prosaic name of ‘the south block’, but later the various buildings were named after the medical deans, according to their chronology, and it became the Hercus building, after third dean Charles Hercus; the earlier buildings were named for the first two deans, John Halliday Scott and Lindo Ferguson.

The Ferguson building (opened 1927), with the Scott building (1917) and Hercus building (1948) in the distance. Image courtesy of the Hocken Collections, University of Otago Medical School Alumnus Association records, MS-1537/637, S17-517c.

The south block was in brick and of similar scale to its neighbours, but the similarities ended there; it was a striking example of art deco, designed by Miller White and Dunn. Hercus recounted how the Minister of Education, Rex Mason, ‘turned down our original severely utilitarian plan with the statement, “This is not a factory, but a national building of great importance, and it must bear the marks of its function”’. The new design incorporated various artworks, most notably a sculptured marble panel by Richard Gross above the main Hanover Street entrance; there were also plaster murals inside. Building was a challenge because of wartime labour and supply shortages; four Dunedin building firms – Love, Naylor, Mitchells and McLellans – formed the Associated Builders consortium to complete the project. Some students obtained holiday work helping with the demolition and ground works for the foundations, which were dug down 15 metres, but the foreman ‘had to keep his eye on them because many would jump the fence and be off’. The building opened in 1948 and boasted 210 rooms; it became a new home for the preventive medicine, pathology and bacteriology departments and had two dedicated research floors, one of them for animals.

The new south block (Hercus building) under construction in the 1940s, looking east along Hanover Street. Image courtesy of the Hocken Collections, University of Otago Medical School Alumnus Association, MS-1537/631, S15-619f.

The next building development was less imposing and not destined to last for long: a single-storey brick building, completed in 1956 next to the Ferguson building, provided a space for the surgery and obstetrics and gynaecology departments. Next to it, on the corner of Frederick and Great King Streets, appeared in 1963 the Wellcome Research Institute. Funded entirely by the Wellcome Trust, which was created from a pharmaceutical fortune, the new building was a tribute to the important research on hypertension by Otago medical professor Horace Smirk, and provided a space for various research teams. It soon developed the nickname ‘Hori’s whare’, while the dental school was ‘Jack’s shack’ after dental dean John Walsh and the pharmacology department in the old Knox Sunday school was ‘Fred’s shed’ after its professor, Fred Fastier. The Wellcome building was designed by Niel Wales, the latest generation in old Dunedin firm Mason and Wales, which had also been responsible for the Scott building; the new building’s international style, with its simple forms and lack of ornamentation, reflected the architectural fashion of the period.

The next buildings took the medical campus further into the realms of new architecture. In 1972 the medical library acquired a new home in the Sayers building, named for the fourth dean, Ted Sayers. The building, which replaced the 1950s surgery and O & G construction, also included accommodation for the medical school administration. A year later the multi-storey Adams building (Bill Adams was the fifth dean) emerged behind it, with an entrance from Frederick Street; it provided new space for the preventive and social medicine, pharmacology, pharmacy and surgery departments, along with the university’s higher education development centre. The Sayers building was designed by Alan Neil of Fraser Oakley Pinfold. A 1994 exhibition on University of Otago architecture suggested his ‘use of fair-faced concrete is an essay in Brutalism’. The Adams building was designed by Miller White and Dunn and the design was recycled in the microbiology building, opened in 1974 on Cumberland Street. The 1994 exhibition noted its utilitarian architecture: it ‘appears to have been designed from the inside out’ and ‘no thought appears to have been given to the external appearance .… Built in the tradition of tower blocks in a park-way, it does not invite inspection of detailing’.

The new Sayers (front) and Adams buildings in the 1970s. Image courtesy of the Hocken Collections, University of Otago Medical School Alumnus Association records, MS-1537/665, S17-517d.

With the 1970s buildings completed, Lindo Ferguson’s 1910s vision of a medical school encompassing the length of the block was fulfilled. Indeed, the school was already spreading much further afield, with microbiology and biochemistry buildings on the new science campus in Cumberland Street and new developments in Christchurch and Wellington. At its Great King Street home base, the school was a showcase of 20^th century architecture, from neoclassicism and art deco to international style and brutalism. Across the street, Dunedin Hospital, whose presence had drawn the medical school to this location, also went through multiple developments. That, however, is a whole other story.

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Of pills and potions and poisons

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1870s, 1880s, 1890s, 1900s, 1920s, 1940s, 1950s, 1960s, 1970s, 1980s, 1990s, chemistry, medicine, pharmacology, pharmacy, physiology, toxicology, Wellington

Making up supplies of the new wonder drug, penicillin, in the pathology department’s sterile solutions unit in 1949. In the 1960s the new pharmacy school took over ‘the factory’. Please get in touch if you can identify the woman in this photo! Image courtesy of the Hocken Collections, Prime Minister’s Department photograph, Box-184-007, S16-102a.

The University of Otago’s interest in pills and potions and poisons dates back to its earliest years. In his first annual report on the university laboratory, in 1875, chemistry professor James Black listed all the analyses he had carried out for the public and local officials. They ranged widely, from food and drink he tested for adulteration to coal and minerals and cement he tested for quality. Also on the list were some samples which suggest intriguing mysteries: in June 1874 Dr Niven of Roxburgh sent medicine, pills, a piece of tart and some lung balsam for testing, while in October Dr Cole of Tokomairiro sent urine and other samples to be tested for poison. Toxicology was thus at the very origin of Otago’s work in the pharmacology field.

It was the establishment of the medical school, though, which led to the first employment of a specialist in drugs. In 1883 John Macdonald was appointed lecturer in materia medica, as pharmacology was then known. The first medical school historian, Dudley Carmalt Jones, described Macdonald as ‘a big, handsome Scotsman of a striking presence …. a man who never quarrelled, and never did anything unethical’. As well as teaching students about drugs, he gave clinical teaching as one of the Dunedin Hospital honorary staff, his specialty being skin diseases. Macdonald taught materia medica according to ‘Edinburgh tradition’, with long lists of drug preparations to be memorised. Students also learned the practical skills of pharmacy, including the visual recognition of drugs and the making of pills, ointments and potions. These skills were taught at the hospital by its dispenser. The first to teach medical students their pharmacy skills was Dr John Brown, ‘a dear old eccentric teacher’ who was hospital dispenser for many years. This well-known character was apparently quite lenient with the students, but his successor refused to sign them off as ‘fully competent’, only recording that they had ‘regularly attended’; he also suggested that ‘grave danger’ could be avoided if they learned the theory of materia medica before tackling the making of medicines.

Although the early pharmacology lecturers focused on teaching rather than research, there were some interesting studies taking place around the university. As I wrote in an earlier post on this blog, New Zealand’s first home-grown medical graduate, Ledingham Christie, was awarded an MD degree in 1890 for his research into the toxicity of the tutu plant. In time-honoured mad scientist fashion, after observing the effects of the tutu berry on cats, roosters and rabbits he tested it on himself, taking a month to fully recover! Otago’s first physiology professor, John Malcolm, began working on tutin soon after his 1905 arrival, together with research assistant and hospital physician Frank Fitchett. Their authoritative study On the Physiological Action of Tutin was published in 1909. The following year Fitchett – a local lad who had returned to Dunedin after completing the final years of his medical training in Edinburgh – became pharmacology lecturer. Medical students enjoyed his lectures, even though they took place at 8am, for he filled them with a great fund of entertaining anecdotes from his years of medical practice. In 1920 Fitchett was promoted to be part-time professor of clinical medicine and therapeutics. He visited medical schools in England and Scotland to check out their pharmacology programmes; Otago needed to adapt its teaching to meet the changing requirements of the General Medical Council. Practice in hospital dispensing – ‘condemned’ as unnecessary by the council – was dropped from Otago’s medical syllabus and replaced with a practical class, modelled on Edinburgh’s, in the writing and analysing of prescriptions, and observation of the effects of drugs.

In 1940, after Fitchett retired, Otago had the good fortune to recruit the brilliant Horace Smirk to a new full-time professorial post in medicine. He was a Manchester graduate who worked in London and Vienna before becoming pharmacology professor in Cairo; he continued his pioneering work on drug treatment for high blood pressure in Dunedin. The new professor started out with a boosted staff of lecturers and researchers and within a few years had added further to his team. It was largely in honour of Smirk’s work that Otago received a large grant from the Wellcome Trust in 1961 for a new research building. Smirk had ‘tremendous vitality’, recalls Fred Fastier, one of his pharmacology team (later a professor himself). His colleagues wondered if this had something to do with the enormous quantities of tea he consumed; was his ‘curiously strong brew’ converted into something special ‘by a process apparently acquired in the land of Egypt’? It didn’t, however, work the same way for them.

Meanwhile, the Medical Research Council set up a toxicology research unit at Otago in 1955. Frank Denz was recruited back from England to his home country as first director; with a team including chemist Jack Dacre he began work on food additives such as colouring agents, ‘chosen because they were in extensive use but had not had adequate toxicological assessment’. Denz also taught in the pathology department; after his death in 1960 a very small team carried on with toxicology research. In 1968 the MRC convinced Garth McQueen of the pharmacology department to become director of the unit; he was an Australian who came to Otago in 1954 to work on hypertension with Horace Smirk and stayed on as lecturer in clinical pharmacology. In 1964 McQueen established the New Zealand National Poisons Information Centre, inspired by Dacre’s observations during study leave in the United States. It started out as a one-man operation, run from the Dunedin Hospital Emergency Department, and grew into a busy standalone 24/7 public service with an enormous knowledge base; alongside it McQueen developed New Zealand’s Centre for Adverse Drug Reactions and the Intensive Medicines Monitoring Programme (IMMP). Developed in the wake of the thalidomide tragedy, these, too, provided important public services, recognised with dedicated government funding from 1982 (the IMMP closed in 2013 after losing funding).

Another important 1960s development started out in a very small way: in 1963 six students signed on for a new Otago pharmacy degree. Pharmacists had been pushing for higher education for decades. New Zealand had been registering pharmacists since 1881, requiring them to complete an apprenticeship and pass exams; various private colleges developed. In 1960 the profession finally succeeded in getting a new pharmacy diploma course underway at the Central Institute of Technology (CIT); the Otago degree course was intended for those destined for specialist positions as researchers, lecturers, hospital pharmacists or manufacturing pharmacists. Pharmacy academics were thin on the ground, so the vice-chancellor persuaded pharmacologist and ‘born optimist’ Fred Fastier to administer the new course. Two highly regarded local pharmacists – analytical and consulting chemist Roy Gardner and Dunedin Hospital chief pharmacist John Conroy – ‘came to the rescue’ and became part-time lecturers for the specialist pharmacy subjects. The old Dental School Annexe (next to what is now the Marples Building) was converted to provide specialised labs for the pharmacy programme and sterile solutions unit, which pharmacy took over from the pathology department. The sterile unit – better known as ‘the factory’ – had been manufacturing supplies, including solutions of penicillin and other drugs, for many years to sell around the country; the pathology professor had kept it going in the hope it would prove useful for a future pharmacy department.

Pharmacy student Alan McClintock and technician Sandra Barkman identifying ‘unknown’ chemical compounds in Rob McKeown’s pharmaceutical chemistry lab, c.1983. Image courtesy of Hocken Collections, University of Otago Photographic Unit records, MS-4368/085, S16-669c.

There was plenty of demand for Otago pharmacy graduates and lots of interest in the course; the annual intake was quickly increased to 20 and in 1975 to 25. In 1971 Harry Taylor, who had been heading the CIT programme, became Otago’s first pharmacy professor. A 1981 retirement tribute noted that Taylor saw pharmacy flourish ‘in the most decrepit building in the university, with his administrative work performed in an office no bigger than a commodious cupboard’, but in 1985 it finally moved into better accommodation in the renovated Adams Building. The pharmacy programme was also renovated under energetic Canadian professor Donald Perrier, who introduced a more clinical focus to the degree, which was popular with students. The class continued to grow, taking its biggest jump in 1991; that year, following a long period of political wrangling, a degree became the minimum standard of entry to the pharmacy profession, the CIT course closed and all New Zealand pharmacy training shifted to Otago (from 1999 pharmacists could also qualify through the University of Auckland). The pharmacy department was upgraded to become the pharmacy school, with Peter Coville – affectionately known as Papa Smurf – as first dean.

While pharmacy developed its own postgraduate programmes and research, staff in pharmacology, psychology and several medical school clinical departments also continued a wide variety of research concerning pills and potions and poisons. Some of these had big consequences. In the 1970s McQueen and Otago paediatricians were among those who revealed the toxicity of popular antiseptic hexachlorophene on premature babies. It was widely used from the 1950s onwards in the fight against staph outbreaks in maternity hospitals, but carried its own dangers. Perhaps the most dramatic finding concerning prescribed drugs came through a group of young researchers at the Wellington campus in the late 1980s. Physicians Julian Crane and Richard Beasley and pharmacologist Carl Burgess, all from the medicine department, were suspicious that a popular asthma drug, fenoterol (marketed here as Berotec), might be contributing to an unexplained epidemic of asthma deaths. They asked epidemiologist Neil Pearce of the Wellington campus’s public health department to join them in a study. The results, published in the Lancet in 1989, were explosive, revealing an association between asthma deaths and fenoterol. As with many epidemiological studies, the findings proved controversial. The drug manufacturer, Boehringer Ingelheim, conducted a remarkable campaign to discredit the study, but they weren’t the only ones to dispute it: other researchers, including some of Otago’s own, also resisted suggestions that fenoterol was dangerous. Further studies confirmed the asthma research group’s findings and government subsidies for fenoterol were withdrawn; it was research which prevented many asthma deaths in New Zealand and around the world. From investigating suspicious lung balsams in the 1870s to uncovering dangerous asthma inhalers in the 1980s, we have many reasons to be grateful to Otago researchers.